2025 NFL Odds Week 1: Strains, Spreads for all 16 Video games

The first Sunday of the NFL season is here.

The defending Super Bowl champion Philadelphia Eagles kicked things off Thursday night with a 24-20 win over the rival Dallas Cowboys.

Friday brought the NFL’s second-ever regular-season game in South America, with the Los Angeles Chargers edging the Kansas City Chiefs 27-21 in São Paulo, Brazil.

With a loaded Week 1 slate, let’s check out the lines for each game at DraftKings Sportsbook as of Sept. 7. 

(All times ET)

2025 NFL Week 1 Odds

THURSDAY, SEPT. 4

EAGLES 24, COWBOYS 20 (DAL covers)

FRIDAY, SEPT. 5

CHARGERS 27 (LAC covers), CHIEFS 21

SUNDAY, SEPT. 7

RAIDERS @ PATRIOTS (1 p.m., CBS)

Point spread: Patriots -2.5 (Patriots favored to win by 2.5 points or more, otherwise Raiders cover)
Moneyline: Patriots -148 favorites to win (bet $10 to win $16.76 total); Raiders +124 underdogs to win (bet $10 to win $22.40 total)
Total Over/Under: 44.5 points scored by both teams combined

STEELERS @ JETS (1 p.m., CBS)

Point spread: Steelers -3 (Steelers favored to win by 3 points or more, otherwise Jets cover)
Moneyline: Steelers -155 favorites to win (bet $10 to win $16.45 total); Jets +130 underdogs to win (bet $10 to win $23.00 total)
Total Over/Under: 37.5 points scored by both teams combined

DOLPHINS @ COLTS (1 p.m., CBS)

Point spread: Colts -1.5 (Colts favored to win by 1.5 points or more, otherwise Dolphins cover)
Moneyline: Colts -112 favorites to win (bet $10 to win $18.93 total); Dolphins -108 underdogs to win (bet $10 to win $19.26 total)
Total Over/Under: 47.5 points scored by both teams combined

CARDINALS @ SAINTS (1 p.m., CBS)

Point spread: Cardinals -6 (Cardinals favored to win by 6 points or more, otherwise Saints cover)
Moneyline: Cardinals -298 favorites to win (bet $10 to win $13.70 total); Saints +220 underdogs to win (bet $10 to win $32 total)
Total Over/Under: 44.5 points scored by both teams combined

GIANTS @ COMMANDERS (1 p.m., FOX and FOX Sports app)

Point spread: Commanders -6 (Commanders favored to win by 6 points or more, otherwise Giants cover)
Moneyline: Commanders -285 favorites to win (bet $10 to win $13.51 total); Giants +230 underdogs to win (bet $10 to win $33 total)
Total Over/Under: 45.5 points scored by both teams combined

PANTHERS @ JAGUARS (1 p.m., FOX and FOX Sports app)

Point spread: Jaguars -4.5 (Jaguars favored to win by 4.5 points or more, otherwise Panthers cover)
Moneyline: Jaguars -205 favorites to win (bet $10 to win $14.88 total); Panthers +170 underdogs to win (bet $10 to win $27 total)
Total Over/Under: 46.5 points scored by both teams combined

BENGALS @ BROWNS (1 p.m., FOX and FOX Sports app)

Point spread: Bengals -5.5 (Bengals favored to win by 5.5 points or more, otherwise Browns cover)
Moneyline: Bengals -250 favorites to win (bet $10 to win $14 total); Browns +205 underdogs to win (bet $10 to win $30.50 total)
Total Over/Under: 47.5 points scored by both teams combined

BUCCANEERS @ FALCONS (1 p.m., FOX and FOX Sports app)

Point spread: Buccaneers -1.5 (Buccaneers favored to win by 1.5 points or more, otherwise Falcons cover)
Moneyline: Buccaneers -122 favorites to win (bet $10 to win $18.20 total); Falcons +102 underdogs to win (bet $10 to win $20.20 total)
Total Over/Under: 47.5 points scored by both teams combined

TITANS @ BRONCOS (4:05 p.m., FOX and FOX Sports app)

Point spread: Broncos -8.5 (Broncos favored to win by 8.5 points or more, otherwise Titans cover)
Moneyline: Broncos -425 favorites to win (bet $10 to win $12.35 total); Titans +330 underdogs to win (bet $10 to win $43 total)
Total Over/Under: 42.5 points scored by both teams combined

49ERS @ SEAHAWKS (4:05 p.m., FOX and FOX Sports app)

Point spread: 49ers -1.5 (49ers favored to win by 1.5 points or more, otherwise Seahawks cover)
Moneyline: 49ers -122 favorites to win (bet $10 to win $18.20 total); Seahawks +102 underdogs to win (bet $10 to win $20.20 total)
Total Over/Under: 43.5 points scored by both teams combined

LIONS @ PACKERS (4:25 p.m., CBS)

Point spread: Packers -1.5 (Packers favored to win by 1.5 points or more, otherwise Lions cover)
Moneyline: Packers -125 favorites to win (bet $10 to win $18 total); Lions +105 underdogs to win (bet $10 to win $20.50 total)
Total Over/Under: 47.5 points scored by both teams combined

TEXANS @ RAMS (4:25 p.m., CBS)

Point spread: Rams -3 (Rams favored to win by 3 points or more, otherwise Texans cover)
Moneyline: Rams -166 favorites to win (bet $10 to win $16.02 total); Texans +140 underdogs to win (bet $10 to win $24.00 total)
Total Over/Under: 43.5 points scored by both teams combined

RAVENS @ BILLS (8:20 p.m., NBC)

Point spread: Ravens -1.5 (Ravens favored to win by 1.5 points or more, otherwise Bills cover)
Moneyline: Ravens -120 underdogs to win (bet $10 to win $18.33 total); Bills +100 favorites to win (bet $10 to win $20 total)
Total Over/Under: 50.5 points scored by both teams combined 

MONDAY, SEPT. 8

VIKINGS @ BEARS (8:15 p.m., ESPN)

Point spread: Vikings -1.5 (Vikings favored to win by 1.5 points or more, otherwise Bears cover)
Moneyline: Vikings -122 favorites to win (bet $10 to win $18.20 total); Bears +102 underdogs to win (bet $10 to win $20.20 total)
Total Over/Under: 43.5 points scored by both teams combined

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