2025 NFL OPOY Odds: Derrick Henry Favored; Barkley Drops

Philadelphia’s Saquon Barkley’s record-breaking season in 2024-25 earned him NFL Offensive Player of the Year honors.

But that was last season.

Could the Philly star be upended at the conclusion of this NFL campaign?

Let’s check out the odds at DraftKings Sportsbook as of Sept. 9.

2025-26 Offensive Player of the Year

Saquon Barkley, Eagles: +650 (bet $10 to win $75 total)
Ja’Marr Chase, Bengals: +950 (bet $10 to win $105 total)
Jahmyr Gibbs, Lions: +950 (bet $10 to win $105 total)
Bijan Robinson, Falcons: +1600 (bet $10 to win $170 total)
Nico Collins, Texans: +1700 (bet $10 to win $180 total)
Justin Jefferson, Vikings: +1700 (bet $10 to win $180 total)
Derrick Henry, Ravens: +1800 (bet $10 to win $190 total)
Puka Nacua, Rams: +2000 (bet $10 to win $210 total)
CeeDee Lamb, Cowboys: +2000 (bet $10 to win $210 total)
Christian McCaffrey, 49ers: +2200 (bet $10 to win $230 total)
Amon-Ra St. Brown, Lions: +3000 (bet $10 to win $310 total)
Tyreek Hill, Dolphins: +3000 (bet $10 to win $310 total)
Malik Nabers, Giants: +3000 (bet $10 to win $310 total)
Brian Thomas Jr., Jaguars: +3500 (bet $10 to win $360 total)
Lamar Jackson, Ravens: +4000 (bet $10 to win $410 total)

Last season, Barkley rushed for 2,005 yards and 13 scores. He had 14 different games in which he hit the 100-yard rushing mark (including the postseason).

With that, he entered the season as the +650 favorite.

But after Philly’s Week 1 win over Dallas, in which he tallied 60 rushing yards and one touchdown on 18 carries, Barkley dropped to fifth on the board at +1000.

To be fair, it appears to be less about what Barkley did and more about what a few rival running backs produced. 

Baltimore’s Derrick Henry ran all over the Bills in Week 1 (18 carries, 169 yards, two TDs), and both San Francisco’s Christian McCaffrey (22 rushes, 69 yards and nine receptions, 73 yards) and Atlanta’s Bijan Robinson (12 rushes, 24 yards and six receptions, 100 yards, one TD) had stellar days running and catching the ball. 

Henry and Barkley spent much of last season dueling at the top of the OPOY oddsboard, before Barkley crossed the 2,000-yard rushing mark and essentially sealed the deal. Henry was far from a slouch, racking up 1,921 yards and 16 rushing TDs (tied for most in the NFL).

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, and follow leagues, teams and players to receive a personalized newsletter daily!