The affected person: A 29-year-old girl in Lithuania
The signs: The lady had been attempting to conceive together with her male accomplice however had not develop into pregnant. Two rounds of in vitro fertilization (IVF) additionally failed to supply a being pregnant, however gynecological exams didn’t discover any underlying causes for why she was unable to develop into pregnant. (When the affected person’s docs described the case in a report, they didn’t point out if any fertility checks have been additionally performed on her accomplice.)
Nevertheless, the girl had a historical past of bronchial asthma and sensitivity to inhaled allergens, resembling mould, cat fur and mud. So she visited a medical facility to see if her allergy symptoms is perhaps affecting her fertility.
What occurred subsequent: On the facility, blood checks revealed that the girl had unusually excessive quantities of eosinophils, a kind of white blood cell that defends the physique in opposition to allergens. Pores and skin checks confirmed that, along with the girl’s recognized allergy triggers, she was delicate to mites, pollen from weeds and grasses, and allergens from bugs and canines.
The affected person was particularly delicate to a protein known as Canis familiaris allergen 5 (Can f 5), which is present in canine dander and urine. Sensitivity to Can f 5 can even point out sensitivity to comparable kinds of proteins present in human semen, the docs wrote within the report.
In an interview with an allergist on the facility, the affected person confirmed that she skilled nasal congestion and sneezing after unprotected intercourse together with her male accomplice. These signs have been beforehand ignored by different specialists throughout consultations about her lack of ability to conceive, she reported.
The analysis: Medical doctors then performed additional allergy checks utilizing samples of semen collected from the girl’s accomplice. The affected person’s allergic response confirmed the docs’ suspicions that she had a human seminal plasma allergy. (Seminal plasma is the fluid part of semen that carries the sperm cells.)
Sensitivity to semen “is a possible explanation for feminine infertility,” as a result of such allergy symptoms can set off irritation in reproductive organs, in accordance with the report. It is not instantly clear if the allergy someway sophisticated the girl’s IVF therapies, as properly, given semen wouldn’t have been current within the implanted embryos.
The therapy: Barrier contraception — particularly, condom use — is the most typical intervention for a semen allergy. Nevertheless, the affected person was nonetheless desperate to conceive together with her accomplice, so she rejected that technique.
The one recognized therapy for decreasing sensitivity to semen includes introducing the fluid into the affected person’s physique in steadily rising concentrations, to construct up their tolerance to the allergens. However this course of therapy was unavailable in Lithuania, the docs wrote. As a substitute, they advisable that the girl take antihistamine treatment earlier than intercourse to scale back the severity of her allergic reactions.
She adopted their directions however discovered this method “ineffective,” the docs wrote. Throughout a follow-up go to three years later, the girl stated that she had nonetheless been unable to conceive. What’s extra, new allergic signs now appeared after contact together with her accomplice’s semen, together with a burning sensation in her vulva, puffy eyelids and watery eyes. No additional therapies have been advisable, in accordance with the report.
What makes the case distinctive: Worldwide, medical specialists have documented about 80 circumstances of human seminal plasma allergy, and there’s nonetheless a lot to be discovered about its impression on being pregnant, particularly within the presence of different health-related points that would hinder conception.
The causes of infertility are sometimes tough to pinpoint. Due to this fact, “this case serves as a reminder that seemingly unrelated allergic situations, when mixed, can contribute to reproductive well being challenges, warranting complete evaluations,” the girl’s docs wrote.
This text is for informational functions solely and isn’t meant to supply medical recommendation.
